Cohort study of workers at a New Zealand agrochemical plant to assess the effect of dioxin exposure on mortality.

ABSTRACT:

Objectives

To describe how the exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) influenced mortality in a cohort of workers who were exposed more recently, and at lower levels, than other cohorts of trichlorophenol process workers.

Design

A cohort study.

Setting

An agrochemical plant in New Zealand PARTICIPANTS: 1,599 men and women working between 1 January 1969 and 1 November 1988 at a plant producing the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) with TCDD as a contaminant. Cumulative TCDD exposure was estimated for each individual in the study by a toxicokinetic model.

Primary outcome measures

Calculation of cause-specific standardised mortality ratios (SMRs) and 95% confidence intervals (95% CI's) compared those never and ever expose

SUBMITTER: McBride DI 

PROVIDER: S-EPMC6196860 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature