A model for the regulation of follicular dendritic cells predicts invariant reciprocal-time decay of post-vaccine antibody response.

ABSTRACT: Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory control model is proposed which links persistence of humoral immunity with cellular processes associated with FDCs. The argument comprises three elements. The first is a literature review of population-level studies of post-vaccination antibody persistence. It is found that reciprocal-time (∝1/t) decay of antibody levels is widely reported, over a range of ages, observation times and vaccine types. The second element is a mathematical control model for cell population decay f

SUBMITTER: Almudevar A 

PROVIDER: S-EPMC6197053 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature