A comparison of inverted and upright laser-activated titanium nitride micropyramids for intracellular delivery.

ABSTRACT: The delivery of biomolecules into cells relies on porating the plasma membrane to allow exterior molecules to enter the cell via diffusion. Various established delivery methods, including electroporation and viral techniques, come with drawbacks such as low viability or immunotoxicity, respectively. An optics-based delivery method that uses laser pulses to excite plasmonic titanium nitride (TiN) micropyramids presents an opportunity to overcome these shortcomings. This laser excitation generates localized nano-scale heating effects and bubbles, which produce transient pores in the cell membrane for payload entry. TiN is a promising plasmonic material due to its high hardness and thermal stability. In this study, two designs of TiN micropyramid arrays are constructed and tested. These desig

SUBMITTER: Raun A 

PROVIDER: S-EPMC6197185 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature