Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6197287 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181022 1
Heterozygous deletion of chromosome 17p (17p) is one of the most frequent genomic events in human cancers. Beyond the tumor suppressor TP53, the POLR2A gene encoding the catalytic subunit of RNA polymerase II (RNAP2) is also included in a ~20-megabase deletion region of 17p in 63% of metastatic castration-resistant prostate cancer (CRPC). Using a focused CRISPR-Cas9 screen, we discovered that heterozygous loss of 17p confers a selective dependence of CRPC cells on the ubiquitin E3 ligase Ring-Bo ...[more]