Cognitive control neuroimaging measures differentiate between those with and without future recurrence of depression.

ABSTRACT:

Background

Major Depressive Disorder (MDD) is a prevalent, disruptive illness. A majority of those with MDD are at high risk for recurrence and increased risk for morbidity and mortality. This study examined whether multimodal baseline (and retest) Cognitive Control performance and neuroimaging markers (task activation and neural connectivity between key brain nodes) could differentiate between those with and without future recurrence of a major depressive (MD) episode within one year. We hypothesized that performance and neuroimaging measures of Cognitive Control would identify markers that differ between these two groups.

Methods

A prospective cohort study of young adults (ages 18-23) with history (h) of early-onset MDD (N = 60), now remitted, and healthy young adults (N =

SUBMITTER: Langenecker SA 

PROVIDER: S-EPMC6197328 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature