Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism.

ABSTRACT:

Background

Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficiency remain poorly understood and require further investigation.

Methods

To explore the pathophysiological processes related to glucocorticoid deficiency, we have performed global transcriptional, post-transcriptional and metabolic profiling of a cortisol-deficient zebrafish mutant with a disrupted ferredoxin (fdx1b) system.

Findings

fdx1b^−/− mutants show pervasive reprogramming of metabolism, in particular of glutamine-dependent pathways such as glutathione metabolism, and exhibit changes of oxi

SUBMITTER: Weger M 

PROVIDER: S-EPMC6197330 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature