Investigation of candidate genes for osteoarthritis based on gene expression profiles.

ABSTRACT:

Objective

To explore the mechanism of osteoarthritis (OA) and provide valid biological information for further investigation.

Methods

Gene expression profile of GSE46750 was downloaded from Gene Expression Omnibus database. The Linear Models for Microarray Data (limma) package (Bioconductor project, http://www.bioconductor.org/packages/release/bioc/html/limma.html) was used to identify differentially expressed genes (DEGs) in inflamed OA samples. Gene Ontology function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analysis of DEGs were performed based on Database for Annotation, Visualization and Integrated Discovery data, and protein-protein interaction (PPI) network was constructed based on the Search Tool for the Retrieval of I

SUBMITTER: Dong S 

PROVIDER: S-EPMC6197383 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature