The influence of surface modified poly(l-lactic acid) films on the differentiation of human monocytes into macrophages.

ABSTRACT: Macrophages play a crucial role in the biological performance of biomaterials, as key factors in defining the optimal inflammation-healing balance towards tissue regeneration and implant integration. Here, we investigate how different surface modifications performed on poly(l-lactic acid) (PLLA) films would influence the differentiation of human monocytes into macrophages. We tested PLLA films without modification, surface-modified by plasma treatment (pPLLA) or by combining plasma treatment with different coating materials, namely poly(l-lysine) and a series of proteins from the extracellular matrix: collagen I, fibronectin, vitronectin, laminin and albumin. While all the tested films are non-cytotoxic, differences in cell adhesion and morphology are observed. Monocyte-derived macrophages

SUBMITTER: Correia CR 

PROVIDER: S-EPMC6197430 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature