Value of DNA methylation in predicting curve progression in patients with adolescent idiopathic scoliosis.

ABSTRACT:

Background

There is considerable discordance in the curve progression of adolescent idiopathic scoliosis (AIS) patients between monozygotic (MZ) twins, indicating that nongenetic factors must be involved in the curve progression of AIS patients. Epigenetic processes may constitute one of these factors and have not yet been investigated in relation to curve progression in AIS patients.

Methods

The genome and methylome of peripheral monocytes were compared between MZ twins discordant for curve progression. Sets of differentially methylated sites were validated using the MassARRAY platform of Sequenome on additional samples.

Results

In the discovery study, we found evidence suggesting a lack of differences at the genome sequence level and the presence of epigenetic diffe

SUBMITTER: Meng Y 

PROVIDER: S-EPMC6197569 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature