Resting state functional connectivity in patients with remitted psychotic depression: A multi-centre STOP-PD study.

ABSTRACT:

Background

There is paucity of neurobiological knowledge about major depressive disorder with psychotic features ("psychotic depression"). This study addresses this knowledge gap by using resting state functional magnetic resonance imaging (R-fMRI) to compare functional connectivity in patients with psychotic depression and healthy controls.

Methods

We scanned patients who participated in a randomized controlled trial as well as healthy controls. All patients achieved remission from depressive and psychotic symptoms with sertraline and olanzapine. We employed Independent Component Analysis in independent samples to isolate the default mode network (DMN) and compared patients and controls.

Findings

The Toronto sample included 28 patients (mean [SD], age 56·2 [13·7]) an

SUBMITTER: Neufeld NH 

PROVIDER: S-EPMC6197617 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature