Field safety and effectiveness of new visceral leishmaniasis treatment regimens within public health facilities in Bihar, India.

ABSTRACT:

Background

In 2010, WHO recommended the use of new short-course treatment regimens in kala-azar elimination efforts for the Indian subcontinent. Although phase 3 studies have shown excellent results, there remains a lack of evidence on a wider treatment population and the safety and effectiveness of these regimens under field conditions.

Methods

This was an open label, prospective, non-randomized, non-comparative, multi-centric trial conducted within public health facilities in two highly endemic districts and a specialist referral centre in Bihar, India. Three treatment regimens were tested: single dose AmBisome (SDA), concomitant miltefosine and paromomycin (Milt+PM), and concomitant AmBisome and miltefosine (AmB+Milt). Patients with complicated disease or significant co-m

SUBMITTER: Goyal V 

PROVIDER: S-EPMC6197645 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature