Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis.

ABSTRACT:

Background

Calprotectin is produced by neutrophils and macrophages, and released during the acute phase of the ANCA vasculitis. The aim of our study was to determine if serum and urine calprotectin are disease activity and prognosis biomarkers in ANCA vasculitis patients during remission.

Methods

Forty-two ANCA vasculitis patients were included. Twenty-seven patients were in remission phase under immunosuppressive therapy, and 15 patients were in the acute phase. Four healthy controls were included. We determined calprotectin in serum and urine samples at the time of the inclusion. We recorded the incidence of relapse and the evolution of GFR, proteinuria, hematuria, and C reactive protein and ANCA titer during 24 months of follow-up.

Results

In remission phase, serum

SUBMITTER: Martinez Valenzuela L 

PROVIDER: S-EPMC6197669 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature