Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis.

ABSTRACT:

Background

Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases. Pro-inflammatory eicosanoids have been implicated in the pathogenesis of multiple sclerosis since they augment vascular permeability and induce leukocyte migration into the brain. We explored the impact of ketogenic diets on gene expression of biosynthetic enzymes for pro- (ALOX5, COX1, COX2) and anti-inflammatory (ALOX15) eicosanoids in patients with relapsing-remitting multiple sclerosis.

Methods

60 adults were prospectively recruited for this six months randomized controlled trial and the impact of dietary treatment on the Multiple Sclerosis Quality of Life-54 index (ClinicalTria

SUBMITTER: Bock M 

PROVIDER: S-EPMC6197715 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature