Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.

ABSTRACT: Amyloid β (Aβ) oligomers are the predominant toxic species in the pathology of Alzheimer's disease. The prevailing mechanism for toxicity by Aβ oligomers includes ionic homeostasis destabilization in neuronal cells by forming ion channels. These channel structures have been previously studied in model lipid bilayers. In order to gain further insight into the interaction of Aβ oligomers with natural membrane compositions, we have examined the structures and conductivities of Aβ oligomers in a membrane composed of brain total lipid extract (BTLE). We utilized two complementary techniques: atomic force microscopy (AFM) and black lipid membrane (BLM) electrical recording. Our results indicate that Aβ_1-42 forms ion channel structures in BTLE membranes, accompanied by a heterogeneous

SUBMITTER: Lee J 

PROVIDER: S-EPMC6197823 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature