Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition.

ABSTRACT: Monoclonal antibodies are playing an increasing role in both human and animal health. Different strategies of protein and chemical engineering, including humanization techniques of non-human antibodies were applied successfully to optimize clinical performances of antibodies. Despite the emergence of techniques allowing the development of fully human antibodies such as transgenic Xeno-mice, antibody humanization remains a standard procedure for therapeutic antibodies. An important prerequisite for antibody humanization requires standardized numbering methods to define precisely complementary determining regions (CDR), frameworks and residues from the light and heavy chains that affect the binding affinity and/or specificity of the antibody-antigen interaction. The recently generated deep-s

SUBMITTER: Dondelinger M 

PROVIDER: S-EPMC6198058 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature