In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model.

ABSTRACT: Quantum dot (QD) nanoparticles are highly promising contrast agents and probes for biomedical applications owing to their excellent photophysical properties. However, toxicity concerns about commonly used cadmium-based QDs hinder their translation to clinical applications. In this study we describe the in vivo biodistribution and toxicology of indium-based water soluble QDs in rats following intravenous administration. The biodistribution measured at up to 90 days showed that QDs mainly accumulated in the liver and spleen, with similar elimination kinetics to subcutaneous administration. Evidence for QD degradation in the liver was found by comparing photoluminescence measurements versus elemental analysis. No organ damage or histopathological lesions were observed for the QDs treated rats

SUBMITTER: Yaghini E 

PROVIDER: S-EPMC6198065 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature