Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.

ABSTRACT: A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively regulates kinases downstream of T-cell receptor (TCR) and LFA-1, thereby setting thresholds for T-cell activation. Alterations to the quality of TCR and LFA-1 engagement at the immune synapse and the regulation of downstream signals can have profound effects on the type of effector T-cell response induced. Here we describe how IFNγ⁺ Th1 responses are potentiated in Ptpn22^-/- T-cells and in T-cells from mice expressing Ptpn22^R619W (the mouse orthologue of the huma

SUBMITTER: Sanchez-Blanco C 

PROVIDER: S-EPMC6198113 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature