Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre's experience.

ABSTRACT: Primary hyperparathyroidism (PHPT) is a common reason for referral to endocrinology but the evidence base guiding assessment is limited. We evaluated the clinical presentation, assessment and subsequent management in PHPT. Retrospective cohort study. PHPT assessed between 2006 - 2014 (n = 611) in a university hospital. Symptoms, clinical features, biochemistry, neck radiology and surgical outcomes. Fatigue (23.8%), polyuria (15.6%) and polydipsia (14.9%) were associated with PHPT biochemistry. Bone fracture was present in 16.4% but was not associated with biochemistry. A history of nephrolithiasis (10.0%) was associated only with younger age (P = 0.006) and male gender (P = 0.037). Thiazide diuretic discontinuation was not associated with any subsequent change in calcium (P = 0.514). Urine

SUBMITTER: Reid L 

PROVIDER: S-EPMC6198194 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature