Maternal smoking and high BMI disrupt thyroid gland development.

ABSTRACT:

Background

Maternal lifestyle factors, including smoking and increased body weight, increase risks of adult diseases such as metabolic syndrome and infertility. The fetal thyroid gland is essential for the control of fetal metabolic rate, cardiac output, and brain development. Altered fetal thyroid function may contribute to increased disease onset later in life. Here, we investigated the impact of maternal smoking and high maternal weight on human fetal thyroid function during the second trimester.

Methods

Thyroid glands and plasma were collected from fetuses electively terminated in the second trimester (normally progressing pregnancies). Plasma total triiodothyronine (T3) and total thyroxine (T4) were measured by solid-phase extraction-liquid chromatography-tandem mass sp

SUBMITTER: Filis P 

PROVIDER: S-EPMC6198368 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature