PKM2 is not required for pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in human pancreatic cancer, and there have been conflicting reports on the association of PKM2 expression and pancreatic cancer patient survival, but whether PKM2 is required for pancreatic cancer progression is unknown. To investigate the role of PKM2 in pancreatic cancer, we used a conditional allele to delete PKM2 in a mouse model of pancreatic ductal adenocarcinoma (PDAC).

Results

PDAC tumors were initiated in LSL-Kras ^G12D/+ ;Trp53 ^flox/flox ;Pdx-1-Cre (KP^-/-C) mice harboring a conditional Pkm2

SUBMITTER: Hillis AL 

PROVIDER: S-EPMC6198443 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature