Integrin-Rac signalling for mammary epithelial stem cell self-renewal.

ABSTRACT:

Background

Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via receptors such as integrins. Extracellular matrix receptors coordinate important cellular signalling platforms, of which integrins are the central architects. We have previously shown that integrins are required for mammary epithelial development and function, including survival, cell cycle, and polarity, as well as for the expression of mammary-specific genes. In the present study we looked at the role of integrins in mammary epithelial stem cell self-renewal.

Methods

We used an in vitro stem cell assay with primary mouse mammary epithelial cells isolated from

SUBMITTER: Olabi S 

PROVIDER: S-EPMC6198444 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature