A non-canonical role for the proneural gene <i>Neurog1</i> as a negative regulator of neocortical neurogenesis.

ABSTRACT: Neural progenitors undergo temporal identity transitions to sequentially generate the neuronal and glial cells that make up the mature brain. Proneural genes have well-characterised roles in promoting neural cell differentiation and subtype specification, but they also regulate the timing of identity transitions through poorly understood mechanisms. Here, we investigated how the highly related proneural genes Neurog1 and Neurog2 interact to control the timing of neocortical neurogenesis. We found that Neurog1 acts in an atypical fashion as it is required to suppress rather than promote neuronal differentiation in early corticogenesis. In Neurog1^-/- neocortices, early born neurons differentiate in excess, whereas, in vitro, Neurog1^-/-

SUBMITTER: Han S 

PROVIDER: S-EPMC6198467 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature