ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer.

ABSTRACT:

Background

Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role in invasion and metastasis. Actin-like 6A (ACTL6A) is vital for embryogenesis and differentiation and is also critical for metastasis and EMT in hepatocellular carcinoma, as observed in our previous study. In the present study, we further explored the role of ACTL6A in colon cancer metastasis.

Methods

ACTL6A expression levels were analyzed in normal colon, colon adenoma and colon cancer specimens using public databases and tissue samples. ACTL6A expression and its association with clinicopathologic features of colon cancer patients were also analyzed. ACTL6A-overexpression and ACTL6A-knockdown colon cancer cells were u

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC6198485 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature