Characterization of autism spectrum disorder and neurodevelopmental profiles in youth with XYY syndrome.

ABSTRACT:

Background

XYY syndrome is a sex chromosome aneuploidy that occurs in ~ 1/850 male births and is associated with increased risk for neurodevelopmental difficulties. However, the profile of neurodevelopmental impairments, including symptoms of autism spectrum disorder (ASD) in XYY remains poorly understood. This gap in knowledge has persisted in part due to lack of access to patient cohorts with dense and homogeneous phenotypic data.

Methods

We evaluated a single-center cohort of 64 individuals with XYY aged 5-25 years, using a standardized battery of cognitive and behavioral assessments spanning developmental milestones, IQ, adaptive behavior, academic achievement, behavioral problems, and gold-standard diagnostic instruments for ASD. Our goals were to (i) detail the neurode

SUBMITTER: Joseph L 

PROVIDER: S-EPMC6198503 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature