Genotype effects contribute to variation in longitudinal methylome patterns in older people.

ABSTRACT:

Background

DNA methylation levels change along with age, but few studies have examined the variation in the rate of such changes between individuals.

Methods

We performed a longitudinal analysis to quantify the variation in the rate of change of DNA methylation between individuals using whole blood DNA methylation array profiles collected at 2-4 time points (N = 2894) in 954 individuals (67-90 years).

Results

After stringent quality control, we identified 1507 DNA methylation CpG sites (rsCpGs) with statistically significant variation in the rate of change (random slope) of DNA methylation among individuals in a mixed linear model analysis. Genes in the vicinity of these rsCpGs were found to be enriched in Homeobox transcription factors and the Wnt signalling pathway,

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6198530 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature