Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii.

ABSTRACT:

Background

Acinetobacter baumannii is a healthcare-associated pathogen with high rates of carbapenem resistance. Colistin is now routinely used for treatment of infections by this pathogen. However, colistin use has been associated with development of resistance to this agent.

Objectives

To elucidate the phylogenomics of colistin-susceptible and -resistant A. baumannii strain pairs from a cohort of hospitalized patients at a tertiary medical centre in the USA.

Methods

WGS data from 21 pairs of colistin-susceptible and -resistant, XDR clinical strains were obtained and compared using phylogeny of aligned genome sequences, assessment of pairwise SNP differences and gene content.

Results

Fourteen patients had colistin-resistant strains that were highly genetically

SUBMITTER: Mustapha MM 

PROVIDER: S-EPMC6198730 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature