Development and evaluation of a deep learning model for protein-ligand binding affinity prediction.

ABSTRACT:

Motivation

Structure based ligand discovery is one of the most successful approaches for augmenting the drug discovery process. Currently, there is a notable shift towards machine learning (ML) methodologies to aid such procedures. Deep learning has recently gained considerable attention as it allows the model to 'learn' to extract features that are relevant for the task at hand.

Results

We have developed a novel deep neural network estimating the binding affinity of ligand-receptor complexes. The complex is represented with a 3D grid, and the model utilizes a 3D convolution to produce a feature map of this representation, treating the atoms of both proteins and ligands in the same manner. Our network was tested on the CASF-2013 'scoring power' benchmark and Astex Diverse Se

SUBMITTER: Stepniewska-Dziubinska MM 

PROVIDER: S-EPMC6198856 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature