Coated electrospun alginate-containing fibers as novel delivery systems for regenerative purposes.

ABSTRACT:

Aim

The aim of the present work was to develop biodegradable alginate (ALG)-containing fibrous membranes intended for tissue repair, acting as both drug delivery systems and cell growth guidance.

Methods

Membranes were prepared by electrospinning. Since ALG can be electrospun only when blended with other spinnable polymers, dextran (DEX) and polyethylene oxide (PEO) were investigated as process adjuvants. ALG/DEX mixtures, characterized by different rheological and conductivity properties, were prepared in phosphate buffer or deionized water; surfactants were added to modulate polymer solution surface tension. The Design of Experiments (DoE) approach (full factorial design) was used to investigate the role of polymer solution features (rheological properties, surface tension

SUBMITTER: Vigani B 

PROVIDER: S-EPMC6198875 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature