Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Small-molecules that disrupt the binding between glucokinase and glucokinase regulatory protein (GKRP) in the liver represent a potential new class of glucose-lowering drugs. It will, however, take years before their effects on clinically relevant cardiovascular endpoints are known. The purpose of this study was to estimate the effects of these drugs on cardiorenal outcomes by studying variants in the GKRP gene (GCKR) that mimic glucokinase-GKRP disruptors.

Methods

The MEDLINE and EMBASE databases were searched for studies reporting on the association between GCKR variants (rs1260326, rs780094, and rs780093) and coronary artery disease (CAD), estimated glomerular filtration rate (eGFR), and chronic kidney disease (CKD).

Results

In total 5 CAD studies (n = 2

SUBMITTER: Simons PIHG 

PROVIDER: S-EPMC6198948 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature