BDNF rs6265 polymorphism methylation in Multiple Sclerosis: A possible marker of disease progression.

ABSTRACT:

Introduction

Brain-Derived Neurotrophic Factor (BDNF) and its most common polymorphism Val66Met are known to have a role in Multiple Sclerosis (MS) pathogenesis. Evidence is accumulating that there is an involvement of DNA methylation in the regulation of BDNF expression. The aim of this study was to assess in blood samples of MS patients the correlation between the methylation status of the CpG site near BDNF-Val66Met polymorphism and the severity of the disease.

Methods

We recruited 209 MS patients that were genotyped for the BDNF Val66Met polymorphism. For each patient we quantitatively measured the methylation level of cytosine included in the exonic CpG site that can be created or abolished by the Val66Met BDNF polymorphism. Furthermore, we analyzed the clinical history

SUBMITTER: Nociti V 

PROVIDER: S-EPMC6198951 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature