Molecular signatures in IASLC/ATS/ERS classified growth patterns of lung adenocarcinoma.

ABSTRACT:

Background

The current classification of human lung adenocarcinoma defines five different histological growth patterns within the group of conventional invasive adenocarcinomas. The five growth patterns are characterised by their typical architecture, but also by variable tumor biological behaviour.

Aims

The aim of this study was to identify specific gene signatures of the five adenocarcinoma growth patterns defined by the joint IASLC/ATS/ERS working group.

Methods

Total RNA from microdissected adenocarcinoma tissue samples of ten lepidic, ten acinar, ten solid, nine papillary, and nine micropapillary tumor portions was isolated and prepared for gene expression analysis. Differential expression of genes was determined using the R package "LIMMA". The overall significa

SUBMITTER: Zabeck H 

PROVIDER: S-EPMC6198952 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature