A Plasmonic Mass Spectrometry Approach for Detection of Small Nutrients and Toxins.

ABSTRACT: Nutriology relies on advanced analytical tools to study the molecular compositions of food and provide key information on sample quality/safety. Small nutrients detection is challenging due to the high diversity and broad dynamic range of molecules in food samples, and a further issue is to track low abundance toxins. Herein, we developed a novel plasmonic matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) approach to detect small nutrients and toxins in complex biological emulsion samples. Silver nanoshells (SiO₂@Ag) with optimized structures were used as matrices and achieved direct analysis of ~ 6 nL of human breast milk without any enrichment or separation. We performed identification and quantitation of small nutrients and toxins with limit-of-detectio

SUBMITTER: Wu S 

PROVIDER: S-EPMC6199099 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature