The CaspBase: a curated database for evolutionary biochemical studies of caspase functional divergence and ancestral sequence inference.

ABSTRACT: Sequence databases are powerful tools for the contemporary scientists' toolkit. However, most functional annotations in public databases are determined computationally and are not verified by a human expert. While hypotheses generated from computational studies are now amenable to experimentation, the quality of the results relies on the quality of input data. We developed the CaspBase to expedite high-quality dataset compilation of annotated caspase sequences, to maximize phylogenetic signal, and to reduce the noise contributed from public databanks. We describe our methods of curation for the CaspBase and how researchers can acquire sequences from CaspBase.org. Our immediate goal for developing the CaspBase was to optimize the ancestral protein reconstruction (APR) of caspases, and we de

SUBMITTER: Grinshpon RD 

PROVIDER: S-EPMC6199153 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature