Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice.

ABSTRACT: Diet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p < 0.05). The transmissible beneficial effects of FMT were associated with bacteri

SUBMITTER: Lai ZL 

PROVIDER: S-EPMC6199268 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature