Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.

ABSTRACT:

Objective

To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke.

Design

Prospective population based cohort study.

Setting

UK Biobank Study, UK.

Participants

306 473 men and women, aged 40-73 years, recruited between 2006 and 2010.

Main outcome measure

Hazard ratios for a first stroke, estimated using Cox regression. A polygenic risk score of 90 single nucleotide polymorphisms previously associated with stroke was constructed at P<1×10^-5 to test for an association with incident stroke. Adherence to a healthy lifestyle was determined on the basis of four factors: non-smoker, healthy diet, body mass index <30 kg/m², and regular physical exercise.

Results

During a median follow-up of 7

SUBMITTER: Rutten-Jacobs LC 

PROVIDER: S-EPMC6199557 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature