Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study.

ABSTRACT:

Objective

To determine whether the use of angiotensin converting enzyme inhibitors (ACEIs), compared with use of angiotensin receptor blockers, is associated with an increased risk of lung cancer.

Design

Population based cohort study.

Setting

United Kingdom Clinical Practice Research Datalink.

Participants

A cohort of 992 061 patients newly treated with antihypertensive drugs between 1 January 1995 and 31 December 2015 was identified and followed until 31 December 2016.

Main outcome measures

Cox proportional hazards models were used to estimate adjusted hazard ratios with 95% confidence intervals of incident lung cancer associated with the time varying use of ACEIs, compared with use of angiotensin receptor blockers, overall, by cumulative duration of us

SUBMITTER: Hicks BM 

PROVIDER: S-EPMC6199558 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature