Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan.

ABSTRACT:

Background/aim

The genomic role of human mouse double minute 2 (MDM2) in colorectal cancer (CRC) is unclear, therefore, our study aimed to evaluate the contribution of MDM2 genotype to the risk of CRC in Taiwan.

Materials and methods

In this case-control study, MDM2 SNP309 T to G (rs2279744) genotypes were determined and their association with CRC risk were investigated among 362 patients with CRC and 362 age- and gender-matched healthy controls in central Taiwan. In addition, the interaction of MDM2 SNP309 genotypes with personal behaviors and clinicopathological features were also examined.

Results

The percentage of variant GG for the MDM2 SNP309 genotype was 30.9% in the CRC group and 24.0% in the control group, respectively (odds ratio (OR)=1.78, 95% confidence in

SUBMITTER: Yueh TC 

PROVIDER: S-EPMC6199579 | biostudies-literature | 2018 Sep-Oct

REPOSITORIES: biostudies-literature