Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells.

ABSTRACT:

Background

Remodeling of Ca²⁺ signaling is an important step in cancer progression, and altered expression of members of the Ca²⁺ signaling toolkit including the plasma membrane Ca²⁺ ATPases (PMCA proteins encoded by ATP2B genes) is common in tumors.

Methods

In this study PMCAs were examined in breast cancer datasets and in a variety of breast cancer cell lines representing different subtypes. We investigated how estrogen receptor alpha (ER-α) and histone deacetylase (HDAC) inhibitors regulate the expression of these pumps.

Results

Three distinct datasets displayed significantly lower ATP2B4 mRNA expression in invasive breast cancer tissue samples compared to normal breast tissue, whereas the expression of ATP2B1 and ATP2B2 was not alt

SUBMITTER: Varga K 

PROVIDER: S-EPMC6199715 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature