Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains.

ABSTRACT:

Background

In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that equilibrates X-linked gene expression with the autosomes. There are other potential contributions to dosage compensation. Hemizygous autosomal genes located in repressive chromatin domains are often derepressed. If this homolog-dependent repression occurs on the X, which has no pairing partner, then derepression could contribute to male dosage compensation.

Results

We asked whether different chromatin states or topological associations correlate with X chromosome dosage compensation, especially in regions with little MSL occu

SUBMITTER: Lee H 

PROVIDER: S-EPMC6199721 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature