Effects of propofol and etomidate anesthesia on cardiovascular miRNA expression: the different profiles?

ABSTRACT:

Background

The effects of the intravenous anesthetics propofol and etomidate on circulation are significantly different; however, their differing effects on miRNA expression in the cardiovascular system are not clearly understood. The purpose of this study is to investigate the effects of these two anesthetics on miRNA expression profiles in the heart and blood vessels.

Methods

Rats were randomly divided into a propofol group and an etomidate group. Spontaneous breathing was maintained throughout the anesthesia process and the rats' oxygen supply was ensured. Heart and thoracic aorta tissue was harvested 3 h after induction. The expression profiles of cardiovascular miRNAs were detected by microarray 4.0 analysis. Twelve representative miRNAs were selected for qRT-PCR valida

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6199805 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature