Nucleolar Division in the Promastigote Stage of Leishmania major Parasite: A Nop56 Point of View.

ABSTRACT: Nucleogenesis is the cellular event responsible for the formation of the new nucleoli at the end of mitosis. This process depends on the synthesis and processing of ribosomal RNA (rRNA) and, in some eukaryotes, the transfer of nucleolar material contained in prenucleolar bodies (PNBs) to active transcription sites. The lack of a comprehensive description of the nucleolus throughout the cell cycle of the human pathogen Leishmania major prompted us to analyze the distribution of nucleolar protein 56 (Nop56) during interphase and mitosis in the promastigote stage of the parasite. By in silico analysis we show that the orthologue of Nop56 in L. major (LmNop56) contains the three characteristic Nop56 domains and that its predicted three-dimensional structure is also conserv

SUBMITTER: Nepomuceno-Mejia T 

PROVIDER: S-EPMC6199852 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature