Animal models of amyotrophic lateral sclerosis: A comparison of model validity.

ABSTRACT: Animal models are necessary to investigate the pathogenic features underlying motor neuron degeneration and for therapeutic development in amyotrophic lateral sclerosis (ALS). Measures of model validity allow for a critical interpretation of results from each model and caution from over-interpretation of experimental models. Face and construct validity refer to the similarity in phenotype and the proposed causal factor to the human disease, respectively. More recently developed models are restricted by limited phenotype characterization, yet new models hold promise for novel disease insights, thus highlighting their importance. In this article, we evaluate the features of face and construct validity of our new zebrafish model of environmentally-induced motor neuron degeneration and discuss

SUBMITTER: Morrice JR 

PROVIDER: S-EPMC6199948 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature