Conditioned pain modulation identifies altered sensitivity in extremely preterm young adult males and females.

ABSTRACT:

Background

Conditioned pain modulation is a potential biomarker for risk of persistent pain. As early-life experience can alter subsequent somatosensory processing and pain response, we evaluated conditioned pain modulation after extremely preterm birth.

Methods

This observational study recruited extremely preterm (<26 weeks gestation; n=98) and term-born control (n=48) young adults (19-20 yr) from the longitudinal EPICure cohort. Pressure pain threshold (PPT; variable test stimulus lower leg) was measured before, during, and after a conditioning stimulus (contralateral hand immersion; 5°C water; 30 s). Questionnaires assessed current pain, medication use, anxiety, and pain catastrophising.

Results

For participants tolerating conditioning, there were significant main

SUBMITTER: Walker SM 

PROVIDER: S-EPMC6200113 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature