Genome amplification and cellular senescence are hallmarks of human placenta development.

ABSTRACT: Genome amplification and cellular senescence are commonly associated with pathological processes. While physiological roles for polyploidization and senescence have been described in mouse development, controversy exists over their significance in humans. Here, we describe tetraploidization and senescence as phenomena of normal human placenta development. During pregnancy, placental extravillous trophoblasts (EVTs) invade the pregnant endometrium, termed decidua, to establish an adapted microenvironment required for the developing embryo. This process is critically dependent on continuous cell proliferation and differentiation, which is thought to follow the classical model of cell cycle arrest prior to terminal differentiation. Strikingly, flow cytometry and DNAseq revealed that EVT forma

SUBMITTER: Velicky P 

PROVIDER: S-EPMC6200260 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature