SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle.

ABSTRACT: The life cycle of HPV is tied to the differentiation status of its host cell, with productive replication, late gene expression and virion production restricted to the uppermost layers of the stratified epithelium. HPV DNA is histone-associated, exhibiting a chromatin structure similar to that of the host chromosome. Although HPV chromatin is subject to histone post-translational modifications, how the viral life cycle is epigenetically regulated is not well understood. SETD2 is a histone methyltransferase that places the trimethyl mark on H3K36 (H3K36me3), a mark of active transcription. Here, we define a role for SETD2 and H3K36me3 in the viral life cycle. We have found that HPV positive cells exhibit increased levels of SETD2, with SETD2 depletion leading to defects in productive viral

SUBMITTER: Gautam D 

PROVIDER: S-EPMC6200281 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature