ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease.

ABSTRACT:

Background

Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent.

Methods

To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

A total of 29 case-control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the d

SUBMITTER: Liu A 

PROVIDER: S-EPMC6200538 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature