Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection.

ABSTRACT: Neutrophils are an important source of IL-1β secretion in bacterial infections, where they infiltrate affected tissues in log-fold higher numbers than macrophages. Neutrophils also have functional NLRP3 and NLRC4 inflammasomes that can process pro-IL-1β to the bioactive 17-kDa form. In the current study, we examined the role of IL-1β in response to corneal infection with the filamentous fungus Aspergillus fumigatus and found that neutrophils were the predominant source of bioactive IL-1β in the cornea. We also observed that caspase-11^-/- mice exhibit the same susceptibility phenotype as IL-1β^-/-, ASC^-/-, NLRP3^-/-, and caspase-1^-/- mice, with impaired neutrophil recruitment to infected corneas and increased hyphal growth. We furt

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6200591 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature