Relationship between ADAMTS14/rs4747096 gene polymorphism and knee osteoarthritis in Chinese population.

ABSTRACT: To investigate the association between single nucleotide polymorphisms (SNPs) of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 14 (ADAMTS14) gene and susceptibility to knee osteoarthritis (KOA) in Chinese Han population. Using a case-control design, we enrolled 346 KOA patients and 480 healthy controls. Peripheral blood samples were extracted from each subject. Genotype was determined by sequencing PCR products. The genotype frequencies between cases and controls were compared. The genotype distribution was in accordance with Hardy-Weinberg equilibrium. The minor G allele in case group was significantly higher than in the control group (21.4 compared with 8.8%, P=0.000, odds ratio (OR) = 1.71 (95% confidence interval (CI): 1.39-2.11). The GG genotype

SUBMITTER: Ma S 

PROVIDER: S-EPMC6200697 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature