Increasing Dietary Fiber Intake Is Associated with a Distinct Esophageal Microbiome.

ABSTRACT:

Introduction

There is increasing evidence that the microbiome contributes to esophageal disease. Diet, especially fiber and fat intake, is a known potent modifier of the colonic microbiome, but its impact on the esophageal microbiome is not well described. We hypothesized that dietary fiber and fat intake would be associated with a distinct esophageal microbiome.

Methods

We collected esophageal samples from 47 ambulatory patients scheduled to undergo endoscopy who completed a validated food frequency questionnaire quantifying dietary fiber and fat intake. Using 16S high-throughput sequencing, we determined composition of the esophageal microbiome and predicted functional capacity of microbiota based on fiber and fat intake.

Results

Among all samples, the most abundant

SUBMITTER: Nobel YR 

PROVIDER: S-EPMC6200756 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature