Design and self-assembly of hexahedral coordination cages for cascade reactions.

ABSTRACT: The search for supramolecular reactors that contain no catalytically active sites but can promote chemical transformations has received significant attention, but it remains a synthetic challenge. Here we demonstrate a strategy of incorporating bulky and electro-rich aromatic linkers into metallocages to induce cascade reactions. Two hexahedral cages with a framework formula [(Zn₈L₆)(OTf)₁₆] are assembled from six tetrakis-bidentate ligands derived from tetraphenylethylene and eight zinc(II)tris(pyridylimine) centers. The cage cavities can accommodate different molecules such as anthranilamide and aromatic aldehyde through supramolecular interactions, allowing for a cascade condensation and cyclization to produce nonplanar 2,3-dihyroquinazolinones. The reac

SUBMITTER: Jiao J 

PROVIDER: S-EPMC6200784 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature